1st column: Active Layer. Check one layer only if you wish this to be the current layer when you open a drawing.

2nd column: Hidden Layer. "H" denotes hidden layer status. Blank denotes that the layer will be hidden. A grey box means that the hidden/visible status will not be affected by global layer settings

3rd column: Frozen Layer. "F" denotes frozen layer status. Blank denotes that the layer will be thawed. A grey box means that the frozen/thawed status will not be affected by global layer settings

To change the status of a layer, left click in one of the three small boxes.